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DiscussionDoes anyone have a solution to help manage Reclast side effects?
Osteoporosis & Bone Health | Last Active: 22 hours ago | Replies (413)Comment receiving replies
Replies to "It is all from the infusion My bones are inflamed because of the remodeling caused by..."
I also was provided this by a person on here!
Immune-mediated syndromes following intravenous bisphosphonate therapy
Reclast infusion
https://link.springer.com/article/10.1007/s10787-017-0365-9
Abstract
Objectives
Intravenous (IV) infusion of aminobisphosphonates (ABP) induces cytokine release by peripheral blood Vγ9δ2 T cells, resulting in an immediate short-term inflammatory response in up to 50% of patients. We evaluated possible long-term pro-inflammatory effects of IV ABP.
Methods
Retrospective case-series study from one rheumatology specialist’s clinic. 2261 electronic charts were reviewed for administration of ‘zoledronate’ or different brand names of zoledronic acid, and relevant clinical data was retrieved for patients who had received the infusion.
Results
Thirteen patients had recieved zoledronate. In six, new-onset or exacerbation of a previous inflammatory/autoimmune disorder was diagnosed within 3 months following infusion. Of these, one patient developed new-onset rheumatoid arthritis (RA), two polymyalgia rheumatica (PMR), two suffered a flare of Crohn’s disease-related and aromatase inhibitor-induced arthralgias, and one patient acquired autoimmune hemophilia. Pre-existing malignancy and immediate inflammatory response following zoledronate were more frequent in patients experiencing new or worsening immunologic manifestations (3/6 vs. 0/7, and 5/6 vs. 2/7, respectively).
Conclusions
Intravenous ABP may trigger induction of persistent autoimmune syndromes, especially when accompanied by an immediate adverse reaction or pre-existing malignancy.
Please, do not give up! I’ve been going to physical therapy and it has been helping some! You now know that it is not from an injury! And, because of this you can make it get better over time. I try to stay as active as possible and do try to keep up with my exercise! My worst is now my left foot and sleep! I am better able to handle the pain in my shoulders throughout the day but at night, the smallest move and my shoulder pain wakes me right up. I am able to go back to sleep despite my sleep being disrupted by the pain. It takes some ambition on my part and I am not going to allow this medication to ruin my total life! Stay positive and it will get some better, hopefully completely better with time. In the meantime, No more bone density medication for me!