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What are the long-term positive/negatives of taking osteoporosis meds?
Osteoporosis & Bone Health | Last Active: 1 day ago | Replies (21)Comment receiving replies
Mayblin, hi.
That's what I was going to say. Now what am I going to say. Both of your citation choices would have been mine. In the past I've detected that we may have a slight difference of opinion on Evenity.
You've learned that it adds bone, not just in the first 2 or 4 months, but intermittently throughout treatment. Do you weigh in on modeled or remodeled. P1NP rises in the first two months.
love hearing from you
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I read your mind @gently 🙂
Charts from manufacturer and clinical studies show continued bmd increases over 12mo treatment period with Evenity, although the rate of increase declines gradually from beginning months towards the end of 12mo. Could this simply be explained by the strong upswing of P1NP (osteoblasts activity) during very early stages (~2wks post first dosing being strongest)? The pattern of bone marker changes with evenity resembles a pure anabolic, guess what, teriparatide when used with a higher dose once weekly formulated in Japan. This makes us wonder if a short burst of P1NP means a long lasting effects of osteoblasts then to the eventual mineralization, which shows up in dexa scan. Might these prolonged sequential events explain bmd increase throughout 12mo? The dual effects of evenity undoubtedly augment its bone building capability.