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The paradox of testosterone and ADT

Prostate Cancer | Last Active: 1 day ago | Replies (92)

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@dpfbanks

We should know very soon - Firmagon is now on board and also chemo #1 as of yesterday. It would have been interesting to watch the response to the Firmagon fora bit before chemo, but apparently, the ‘authorizations’ go smoother with the whole plan, don’t ya know. Chemo is docetaxel+ carboplatin, which is not standard for mHSPCa - due to ‘high volume’ designation because Mets is in a visceral organ - lung only. Unique presentation = unique response? Suspected transformation already as Hans suggested in this thread?

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Replies to "We should know very soon - Firmagon is now on board and also chemo #1 as..."

Can you ever really know? Can a few rare cases turn enough heads so that doctors will respond differently to the 99.7%?
I don’t know enough about the reason for the inclusion of the carboplatin to speculate but they are certainly hitting those lung nodules hard.
We see many cases where lesions almost disappear with just ADT prior to definitive treatment but here they are going all in and not waiting for anything.
Phil