I take 25 if pain isn't too bad. Sometimes 50 if bad. Bed time 150 to 175. Saw my PAIN MANAGEMENT DR. today. I have a pain pump with helps, Medtronic BUT they changed the BOLUS, it's big, takes a long time to work!! They used have a SMALL BOLUS, WORKED RIGHT AWAY!! NOW ITS BIG!! HEAVY!!! TO GIVE YOUR SELF A DOSE TAKE 15 MIN!!!!!!! HORRIBLE, COMPANY NEVER THOUGHT OF THE "PATIENT " HAVE A GOOD EVENING.