M-Spike and Lambda light chain increasing while KL ratio decreasing

Posted by righty01 @righty01, Apr 17 12:13pm

Was diagnosed with MGUS last spring. in the last 12 months M-Spike has increased .4 to .6 to 1.1 and most recently 1.4. Lambda light chain has gone from 118 to 152 to 160 and most recently 227. Kappa Lambda ratio has gone from .2 to .14 to .09 and most recently .08. IGG is consistently over 1750mg/dl.

Seeing my hematology oncologist in July. He has told me not to be concerned until my Lambda light gets over 1000 and M-Spike is greater than 3.0.

Any thoughts? reason to be concerned?

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

tomy | @tomy | Apr 23 8:26am

In reply to @hsminc "Unfortunately, decisions about MM treatment or no treatment/observation is still an art and not a science..." + (show)

Mayos is doing spectrography research to fine tune diagnoses and treatments

lintait68 | @lintait68 | Apr 23 9:14am

I was diagnosed with MGUS over a year ago while my primary doctor was testing me for Osteoporosis and my M-Spike came back at 0.5. Further testing and a trip to HemeOnc confirmed the diagnosis. I have no symptoms except for numbness at times in my hands (but I've had that for years) and all of my other testing is within normal range except Immunogobulin M-532, Free Kappa Lt Chain, S is 26.6, and now my M Spike is 0.6.
I even went and got a second opinion from one of the big university guys who specialize in Waldenstrohm's Macroglobulinemia, and he said the same exact thing. Basically wait and see. I feel fine.

hsminc | @hsminc | Apr 23 9:52am

In reply to @tomy "Mayos is doing spectrography research to fine tune diagnoses and treatments" + (show)

I am a Mayo (RST) patient and have been for 35 years. Hopefully, if necessary, I will benefit from this research. Thanks for sharing.

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