@rosoto Welcome to Mayo Clinic Connect. Often, we experience varying levels of fatigue that seem to be connected to whatever else we may have going on, or our recent diet, or even weather changes/activity level changes. There are so many factors that can play a part, from my own experience. It's really hard to narrow it down to a particular cause of tiredness or fatigue.

I would not be willing to be real quick at pointing out an MGUS or smoldering myeloma as chief cause for fatigue. That is my own personal opinion. As an example, for myself, in addition to living with multiple myeloma, I am an end-stage kidney disease patient on daily dialysis. Does the myeloma sometimes promote fatigue? Yes, indeed! Does my daily dialysis lend itself towards fatigue at times? Again, yes. And as I continue to push myself to do as much as I can, there are days I push too hard, and pay the price.

What we can do as patients, is be mindful of our diets, choosing to eat healthy, minimize our stress as much as possible, get moderate exercise, and follow our medical team's guidelines for our unique health situation.
Ginger