Your lack of diagnosis puzzles and alarms me. Sulfasalizine is an anti-inflamitory that is broken down by the gut bacteria. It then turns into the mesalimine group that works on the gut. (Hence its use for Crohn's and Ulcerative Colitis ) And the other part works on the whole body as a anti-inflamatory- but not a very strong one by my standards. The symptoms for UC and Crohn's are faily distintive (mostly diarrhea) and aren't easily uncovered by blood work. The docs I've seen seem to prefer to go by symptoms over blood work or at least use a combo of the two. It might be time for a 2nd opinion.