Hello Hank. I had a distal (tail section removed) panreatectomy in 2014 and while I experienced EPI prior to the surgery, it became worse after that. I also take Creon 36000 x 9, but have been taking it so long that I really do not remember how long before I noticed better digestion of nutrients. I do not believe it takes weeks, but more like a few days. Much will depend on how inflamed your pancreas is now; if that is minimal, then you should feel a difference sooner than if it is inflamed when you start the regimen. The enzymes, as I am sure you know, are used for the purpose of helping your pancreas in digestion, but also to give it a rest as it will not be attempting to produce those enzymes you are taking by mouth. Because of opiate pain treatment, I have never dealt with the diarrhea as my problem has always been he opposite. I realize we are dealing with opposite issues, but I take two different meds and, at times, two different over the counter products to try and achieve some level of regularity. I am sorry you are having such a difficult time and will certainly say a prayer for your treatment and recovery. I can't imagine having to live with the symptoms I have and adding chemo on top of that so good on you and Godspeed to wellness.

@gman007 - t/HANK/s for the feedback . . . I just got off Creon today . . . . the sides knocked me for a loop and Dr. Stomach moved me over to Prtyze starting tomorrow . . . the protein in my high carb high protein including the shakes etc. to gain weight have my weight on hold and can't move up the scale . . . the EPI just hit me over night and has been a struggle just like yours is . . . I appreciate the prayers and welcome them as a Believer . . . sending prayers out your way from my wife and I . . . some good news today though - Dr. Cancer believes the tumor is shrinking at a rapid rate and will do the PET in about 3 weeks. Downside is that I had to jump on antibiotics today because my white blood count dropped out of the acceptable range and that's the blood function that helps fight infection . . . . stay in touch @gman and God Bless you and yours /h

I hope the new enzyme works much better and with minimal side effects. Thank God that the tumor is shrinking and I pray it appears even smaller or gone on your PET. Do you buy the premixed shakes or make them yourself. I use whey powder to mix my own and I have to avoid the carbs because part of my EPI is related to insulin production and mix mine with milk and ice and usually some veggies and fruit thrown in the blender. If you need the carbs, you could find a flavor that will mix well with a fruit juice and get even more nutrient rich calories into your body. I am probably telling you many things you already know, but just in case. Thank yo and your wife's prayers - I have been chronically ill for a little over 11 years and between my church, my Mom's, my Mother-in-Laws, and just friends, I would guess I have had hundreds of thousands lifted on my behalf. While I have not experienced a cure, I am supported by the knowledge that so many people are regularly thinking of me and lifting my needs above. Take care and keep us informed.