Thanks to everyone on this forum , I was diagnosed with two mutations middle last year, jak2 and Calr, apparently to have both is complicating treatment. Was on Hydrea for month no change then JAKAVI for 6 weeks no change back on increased Hydrea and injection Aranesp increased dosage with both. No hair loss but the tiredness and weakness when doing anything is tough and tho I never suffered with depression I am having to fight that also. Agree with the conception from friends that they think it's not serious as doesn't conform with other cancers. It is great to hear other views and the positive vibes...