Chronic painful muscle knots, widespread

Has anyone else experienced widespread, painful muscle knots that literally never go away?

For years now I’ve had many painful knots in several areas of my body. I have tried ice, heat, muscle relaxers, over the counter pain medication, and massage/trigger point pressure and NOTHING helps. My spouse can find dozens of hard knots in my face, head, jaw, neck, upper back and shoulders, back, arms and legs. The knots are always there, cause pain without touching the area and cause unbearable pain that is nauseating if pressure is applied to the knot(s). My spouse tries to massage them the make the knot release but it doesn’t help; I just can’t stand the pain and it quickly becomes nauseating. Sometimes the general pain of it (pain that is present without pressing on the knots) is so bad it keeps me awake at night.

What could be causing these knots and pain and what can be done to relieve it?
Thanks