I joined just to add that I too have had neuropathy issues since Mounjaro. I even convinced myself I have MS. I was on semaglutide for 1.5 months, and I think I remember minor numbness in hands and tingling in one foot intermittently. But things really kicked up when I started Mounjaro 7 weeks ago. Extreme tingling and numbness all over but mostly my right leg. allodynia on my right thigh. Some back issues and numbness too. It is really bad the first few days after my injection and then it gets better as the week goes on. By the time it gets a little better it's time for the next injection. I am due for my next injection in 2 days but I won't take it.
I think dehydration from dieting and an uncomfortable bed also could have something to with my problems (I got a new bed right when I started mounjaro). But I also feel mounjaro is the main issue so I don't feel comfortable continuing.
Just an update: I've been diagnosed with drug-induced peripheral neuropathy (DIPN) in my feet from tirzepatide (zepbound). Titrating down on the dosage and then switching to semaglutide has halted the progression, but my neurologist tells me that the initial damage is likely permanent -- fortunately, it's sensory, without pain. I've been on trazodone for migraines which worked well, but ultimately produced tingling and numbness in my arms, so perhaps I had a propensity in this direction. At any rate, it's a known, extremely low probabillity (< 0.4%) side effect.
For what it's worth, I was ultimately diagnosed by neurologist who works with cancer patients. For them, DIPN is a horse -- it occurs in 60% of chemotherapy patients, so they are familiar with it and know how to identify it. For any other neurologist, it's a zebra -- it's so unlikely that they rarely consider it. I was referred to oncology when my PN labs indicated MGUS. Turned out to be a temporary indicator of a prior infection, but it got me in the door to the right person for a diagnosis.
I'm old enough and have been on enough drugs over the years that sooner or later the odds were going to catch up with me, and I would be one of those people who actually turn out to have one of those extremely rare side effects. If we took seriously the possibility that we would be that person, we would probably never take any drugs, and would just die young and in pain from something that could have been treated. So most of the time, I'm just philosophical about losing this particular lottery. Some of the time, though, I can get a bit bitchy about it.
I joined just to add that I too have had neuropathy issues since Mounjaro. I even convinced myself I have MS. I was on semaglutide for 1.5 months, and I think I remember minor numbness in hands and tingling in one foot intermittently. But things really kicked up when I started Mounjaro 7 weeks ago. Extreme tingling and numbness all over but mostly my right leg. allodynia on my right thigh. Some back issues and numbness too. It is really bad the first few days after my injection and then it gets better as the week goes on. By the time it gets a little better it's time for the next injection. I am due for my next injection in 2 days but I won't take it.
I think dehydration from dieting and an uncomfortable bed also could have something to with my problems (I got a new bed right when I started mounjaro). But I also feel mounjaro is the main issue so I don't feel comfortable continuing.
I developed fasciculations and some right foot humming after 5 weeks of Semaglutide use last summer. I discontinued after the 6th week but the twitching did not. The small fasciculations were initially in my calves but eventually and sporadically involve my thighs, obliques and a little in my hands (with some action tremor). All the symptoms are quite mild and intermittent except for one calf. I can go days or a week without fasciculations apart from the one calf. I have no weakness or pain. I am hoping it eventually goes away but it does not seem to be progressing. My concerns about a connection to the medication have been brushed aside to date but I am not going to let it go in case something can be done.
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I joined just to add that I too have had neuropathy issues since Mounjaro. I even convinced myself I have MS. I was on semaglutide for 1.5 months, and I think I remember minor numbness in hands and tingling in one foot intermittently. But things really kicked up when I started Mounjaro 7 weeks ago. Extreme tingling and numbness all over but mostly my right leg. allodynia on my right thigh. Some back issues and numbness too. It is really bad the first few days after my injection and then it gets better as the week goes on. By the time it gets a little better it's time for the next injection. I am due for my next injection in 2 days but I won't take it.
I think dehydration from dieting and an uncomfortable bed also could have something to with my problems (I got a new bed right when I started mounjaro). But I also feel mounjaro is the main issue so I don't feel comfortable continuing.
Just an update: I've been diagnosed with drug-induced peripheral neuropathy (DIPN) in my feet from tirzepatide (zepbound). Titrating down on the dosage and then switching to semaglutide has halted the progression, but my neurologist tells me that the initial damage is likely permanent -- fortunately, it's sensory, without pain. I've been on trazodone for migraines which worked well, but ultimately produced tingling and numbness in my arms, so perhaps I had a propensity in this direction. At any rate, it's a known, extremely low probabillity (< 0.4%) side effect.
For what it's worth, I was ultimately diagnosed by neurologist who works with cancer patients. For them, DIPN is a horse -- it occurs in 60% of chemotherapy patients, so they are familiar with it and know how to identify it. For any other neurologist, it's a zebra -- it's so unlikely that they rarely consider it. I was referred to oncology when my PN labs indicated MGUS. Turned out to be a temporary indicator of a prior infection, but it got me in the door to the right person for a diagnosis.
I'm old enough and have been on enough drugs over the years that sooner or later the odds were going to catch up with me, and I would be one of those people who actually turn out to have one of those extremely rare side effects. If we took seriously the possibility that we would be that person, we would probably never take any drugs, and would just die young and in pain from something that could have been treated. So most of the time, I'm just philosophical about losing this particular lottery. Some of the time, though, I can get a bit bitchy about it.
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3 ReactionsI was on *Liraglutide for 1.5 months not semaglutide
I developed fasciculations and some right foot humming after 5 weeks of Semaglutide use last summer. I discontinued after the 6th week but the twitching did not. The small fasciculations were initially in my calves but eventually and sporadically involve my thighs, obliques and a little in my hands (with some action tremor). All the symptoms are quite mild and intermittent except for one calf. I can go days or a week without fasciculations apart from the one calf. I have no weakness or pain. I am hoping it eventually goes away but it does not seem to be progressing. My concerns about a connection to the medication have been brushed aside to date but I am not going to let it go in case something can be done.