Thank for your question and thanks for your awareness of supplements for this important issue.
The quick answer to your question is that I mostly get Lysine from 3 sources and I alternate between them. Most days I eat canned sardines or tuna "in water", not oil, as studies show water is a healthier choice. Tuna in water has about the same profile as sardines which equates to approximately 2-2,500 mgs per 3 oz can. Sometimes I eat a can of each at the same time with two boiled eggs and some mayonnaise. That would put a value close to 5,000 mgs on those days. Other days I use a scoop of vanilla flavored whey protein mixed with powdered milk and I eliminate one or the other of tuna/sardines. A scoop of whey protein equates to approximately +/- 2,300 mgs.
But Lysine is NOT the total answer. So what does Lysine do? Ask any Pharmacist (doctors may not know) Lysine is a wound healer. It's best known for cold sores around the mouth. taking lysine on a regular basis helps prevent outbreaks of cold sores and genital herpes.
Lipoprotein (a) is also a wound healer that operates in the endothelium (inside the cellular structure of the coronary arteries) of the heart. It's a natural response to the plaque build up in there. It's duty is to "patch up" the inside of the artery wall due to a Vitamin C deficiency. Vitamin C enchances this process. A minimal of 750 mgs of Vitamin C daily has been demonstrated for the process to work along with Lysine. I personally take upwards of 2,000 mgs per day...not all at once. (500 mgs 4 times through out the day). If a person is sensitive to ascorbic acid, (stomach issues), there are other forms, like "neutral" C.
Lp(a) is similar to LDL cholesterol, but it is even more “sticky” than typical LDL cholesterol, making it even better at sticking to artery walls and potentially causing harmful blockages.
If you go to your favorite search engine and type in ("name the lipoproteins"), the first paragraph below is basically what you will find.
"The main classes of lipoproteins, which are classified based on density, are chylomicrons, very low-density lipoproteins (VLDL), intermediate-density Lipoproteins (IDL), low-density Lipoproteins (LDL), and high-density Lipoproteins (HDL)."
Why is lipoprotein (a) never listed...as if it doesn't exist?
If cholesterol is the problem, why don't we see venouscelrosis? Plaque build up in your ear lobe, toes, nose etc? The same blood travels everywhere in the body.
Please study the Gulo gene.
The GULO gene encodes the enzyme L-gulonolactone oxidase, which is crucial for vitamin C biosynthesis in many animals, but is non-functional in humans and other primates due to mutations, resulting in the inability to synthesize vitamin C.
One more thing. MAGNESIUM. Studies show that the majority of people in the United States are deficient in Magnesium. In most of our trials, Magnesium in most cases will help (or sometime eliminate) irregular heartbeat beat. Please study.
Final thoughts. Doctors say (especially Cardiologist) say supplements create expensive urine. You get all the nutrients in your diet. Please let me know if you find all the vitamins and minerals in the foods most people eat today and I'll change my mind. Farmers only put N-P-K fertilizer in the soil. What about the other 60+ minerals that need to be there? The price to add these would cause a farmer to go broke. Plants need all minerals to give humans the daily nutrients. They can't if the minerals are not in the soil. If you know of a commercial farm that provides all nutrients back to the soil, please let me know.
Cardiologist and doctors die from cardiovascular disease just like the rest of us.
Why don't animals have heart attacks and strokes? Look it up.
thanks for the info very good stuff. I've been taking vitamin C a couple thousand milligrams for 50 years and eating low fat for probably 40 or 45 years and every time I wanted my doctor to test me for LP (a) he would tell me why we can't do anything about it so what does it matter. So I have inherited I guess the Gene for high LP (a). I have taken lysine in the past for cold sores and there is a theory that it helps bolster the immune system and some people were taking it when they caught Covid not sure if that had any effect. But Pauling felt that the solution was to use lysine and vitamin C. Also apparently amino acid proline helps?
have you seen any regression in your plaque or calcium in your arteries? Obviously it's important to slow down the process but it would be nice if the body could reverse it to a certain extent.