Two years ago, I started on 100mg Sprycel when Imatinib failed. I had similar side effects immediately- fluid retention, scalp sensitivity, and weird facial pustules. My oncologist cut my dose to 50mg, which has been much better. I also take 20mg furosimide (diuretic) every other day. It keeps the swelling down. All other side effects are minimal now. And my numbers have slowly & steadily gone down.