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M-Spike and Lambda light chain increasing while KL ratio decreasing
Blood Cancers & Disorders | Last Active: 5 hours ago | Replies (9)Comment receiving replies
In your place, I would be concerned. These numbers are all rising, indicating possible progression. You should be followed at frequent intervals with blood tests - maybe every 3 or 6 months. The ratio is decreasing because your lambda FLC is increasing.
When your lambda number over the kappa number equals or exceeds 20, you may have a problem.
Definitely, an M spike of 3 is problematic. However, some hematologists argue that 1.5 is concerning.
Is your doctor a MM specialist? If not, you need to find one to guide your current doctor.
Have you enrolled in SmartPatients.com? This is an online group of mainly MM patients but you can obtain very knowledgeable information from this website.
Best wishes. Feel free to contact me privately.
I have had rising MGUS numbers for 23 years. I am still classified as MGUS.
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Thank you for taking the time to respond to my post. My current Lambda over Kappa is about 13. I have a follow up with my oncologist mid June with another round of bloodwork prior to.
Just want to be proactive and stay ahead of it. Going to be 5 years out from radical prostatectomy surgery in August. Had high grade prostate cancer that was caught very early.....not interested in any last minute surprises!!