← Return to M-Spike and Lambda light chain increasing while KL ratio decreasing
DiscussionM-Spike and Lambda light chain increasing while KL ratio decreasing
Blood Cancers & Disorders | Last Active: 6 hours ago | Replies (9)Comment receiving replies
Replies to "This must be distressing for sure. No one likes seeing lab values going up albeit slowly...."
There are two “schools of thought” these days based on clinical trials. The one school says treat patients early on because they are then progression free, do much better, and overall survival is convincing -
Much better. These trials are out of Dartmouth - Irene Ghobriel.
There are other hematologists who note the high risk MM patients that do just fine under observation and are not exposed to toxic drugs and their side effects; there is also a cohort of patients under observation that do progress. The problem is as I see it, we do not seem to have useful biomarkers that will enable us to know who will progress and who will not. Algorithms do not agree about who is higher risk and who is not.
You need to find a MM subspecialist that can sort your situation out for you - and who falls into which “camp” concerning risk.