← Return to M-Spike and Lambda light chain increasing while KL ratio decreasing

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@msh466

This must be distressing for sure. No one likes seeing lab values going up albeit slowly. There are cutoffs before treatment or clinical studies are started. For me I was like start me now. Pronto. I have SMM and again values slightly go up but not enough to tip the scales. It’s like what are we waiting for Xmas. I feel fine physically. But man the mind and mental stress has aged me some. The little I can do is worry. The most I can do though and this is important is find a good doctor/specialist who can relate to you and treat you when and if the time comes. Instead of wow where did this come from type of scenario. Gain confidence by the one overseeing your care kind of takes the edge off. You’re in for the long haul. The rest of your life actually. And you need someone on your side who will deliver exceptional care you’ve come to expect.

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Replies to "This must be distressing for sure. No one likes seeing lab values going up albeit slowly...."

There are two “schools of thought” these days based on clinical trials. The one school says treat patients early on because they are then progression free, do much better, and overall survival is convincing -
Much better. These trials are out of Dartmouth - Irene Ghobriel.
There are other hematologists who note the high risk MM patients that do just fine under observation and are not exposed to toxic drugs and their side effects; there is also a cohort of patients under observation that do progress. The problem is as I see it, we do not seem to have useful biomarkers that will enable us to know who will progress and who will not. Algorithms do not agree about who is higher risk and who is not.
You need to find a MM subspecialist that can sort your situation out for you - and who falls into which “camp” concerning risk.