How much value to put on the numbers in the Decipher Grid?

Posted by topf @topf, Apr 14 2:54pm

Have you paid any attention to the numbers in your Decipher grid? Or are you just focused on the overall score? The grid pages say “Research Use Only”, but I still wonder how important they may be.

While my score is low at 0.2, there are some features in the grid that worry me:

1) 81st percentile on RT Sensitivity, with a status of “resistant”. It seems that a higher sensitivity score implies more resistance, in line with higher scores being bad. Does this result have implications for RT?

2) 98th percentile for Glycolisis. Does this imply that my tumor is less testosterone dependend and feeds of sugar?

Any insights are highly welcome!

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

@topf

How did you access OpenEvidence without an NPI? Or do you have one?

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It’s been a long time since I used OpenEvidence. I never had to enter a NPI when I began using it, maybe they updated their account set-up requirements….

I switched to perplexity.ai many months ago and like the fact that it provides direct links to the all source materials it uses in for its answers.

As soon as Grok3 was available I began using it and now use it almost exclusively, although I wish it would provide direct links to its source materials like perplexity.ai.

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@topf

Yes, I saw that. He was mainly referring to the 15 year mortality risk. You need 15+ year old sata to estimTe that and mortality has drastically decreased since then. I don’t know if metastatic risk has decreased too.

My understanding is that the grid is still research in progress as the Decipher test is evolving. Jt would be interesting to know what the current state of knowledge is on these characteristics. In my case, e.g., what the implications of high glycolisis would be.

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I had the Decipher Test at 4.5
(Lower half of intermediate?) then somewhere it corresponds to the NCCI
categories. BTW the new UK categories will be published on 22 May 2025, 5x not our 3.
As Dr. Scholz had suggested AI will play a role in figuring out all the relationships to further assist clinicians at some point.

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