Hi, I too am ET CALR diagnosed in 2004, switched to anagrelide following 3 years watch and wait, 10 years HU ( then ulcers) and interferon not working. After that anagrelide has controlled counts well. Am monitored for spleen size through annual ultrasound and heart for any damage from drugs. In 2020 had a new BMB that caught me on the turn to MF. I had the heart CT and have calcium score of zero and Doppler artery scan too, all good. However although I have post ET MF nothing has changed in my treatment as everything has stayed stable and the progression is very slow for me. The main thing is I had lower hemagloblin ( 9.6) so I had one transfusion last year and then felt normal again. It’s no harm to know where you are as there are lots of new treatments coming on line and you may qualify. I feel no different once I got over the shock of progression but the disease is actually a continual line of progression so we are all changing all the time. My spleen is still normal 4 years on too, blasts are low ( tear shaped cells) . Good luck, I hope you feel able to make the decision once way or another.