Hello @earless, your nephrologist and oncologist should be working together to find the best alternative for you. You certainly don't want to be thrown into dialysis by your chemo. I have metastatic SCC also..... for 13 years now. My most recent metastasis was treated with a newer immunotherapy and it has cleared the tumor in my kidney and surrounding lymph nodes. Has anyone mentioned an immunotherapy to you instead of chemo? It might be worth a question to your oncologist. Mayo does a great job of having the specialties working together so if they are not, then start to question your teams why not?