I’m curious about this too. I’m 48 and my platelets are in the critical range at 1,142K. The highest was 1,394 and my oncologist-hematologist said I’d have to start HU if they reach 1,500. He’d like to wait until I’m 60 before starting this, since women’s risk of stroke increases at that age. I was diagnosed with ET relatively young, at 43, and my first count was 697. I only take baby aspirin daily, and stay relatively active for cardiovascular health. I’m curious about what others do to feel some sense of control over this condition.