For me all the meds have really done is keep platelet levels in check. When on HU other symptoms were there and slowly increasing. Probably less rapid on HU than the last 2 years on Jakafi.
I understand the frustration of "slowing down"; just look at everything as positive and even the little things as victories and don't dwell on the negatives (I know this is sometimes easier said than done - I'm impatient with this as well).

anavleek, for me at least HU not only brought down my platelet count, it also gave me my energy back, and relieved those killer ET headaches.

Not only do we have a weird cancer, we all go through it a bit differently.

I guess that makes us very special.