I was put on jakavi after being on hydrea for 6 weeks and wasn't working.however as I am.taking eliquis for atrial fibrillation my consultant was concerned about a possible reaction ....so back on the double dose hydrea and 300 mg aranesp injection ( this I administer every three weeks)..other than slight nausea and metallic taste which I can cope with .its the light headed and weakness if i do.anythimg ..I honestly wonder ami a drama queen as everyone here seems to cope well...if I do simplest chores I have to sit after 5/10 mins feeling weak ..I can't spend rest of my life sitting ( I feel perfect if I stay immobile) so I just wonder has anyone suffered with this fatigue/ weakness ...I was always very active so it's against my nature to be like this