Hemo oncologists in the US have differing opinions about what ET is and how to treat it. Most offer minimal info to patients. This accounts for differing understanding among ET patients and misinformation or conflicting info among patients.

My understanding is that HU only lowers platelet production and thereby helps prevents strokes, clots, and spleen enlargement. It may also reduce effects on liver and kidneys, but I'm fuzzy on that. More ET patients would take Besremi if they could afford it. It is used way more widely in Europe, especially in patients under 40.

Not nearly enough hemos counsel ET patients about how diet and exercise can reduce overall stroke risk or relieve fatigue or other symptoms. And they don't do a great job talking about progression, increased risks of sun exposure, or decreased immunity.