Suzetrigine is not the panacea we had all hoped for. It turns out that I cannot take Suzetrigine because it triggers seizures for me. 9 days ago, after being on it and feeing grateful that finally something was reducing my neuropathy pain, I had 2 seizures in the evening. The second caused me to fall onto a sturdy rocking chair (breaking it and bruising one side of my body) and then landing face-down on the floor, nearly taking out my left eye. I have a partially blind right eye, and if I'd lost my left, I'd now be officially blind. I'm off suz now and the pain has come roaring back. All this happened after I had cleared suz with my neurologist (epileptologist) to be sure it would not interact with my seizure meds. After doing some research online on my own, I realized that suz "induces" a P450 CYP3A4 enzyme to be more active, and the 3A4 enzyme metabolizes (breaks down) some of my seizure meds, thereby lowering my seizure threshold. Suz is new, and not approved for use for chronic pain, but it had gone through phases 1-3 for acute pain, and apparently this did not show up. I recommend that, if you have seizures, you not only check with your neurologist, but use AI and do your own research to determine if the particular anticonvulsants you're taking are metabolized via 3A4.
This applies not only to those of us on seizure meds, but any meds that are metabolized via 3A4.