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Osteoporosis & Bone Health | Last Active: Apr 9 2:13pm | Replies (14)
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Is the bone loss worse than it was before you started the drug? That is a huge fear...like Prolia is supposed to be awful for that. I am already on HRT, started early to help prevent more bone loss than I already had. Is Raloxifene something special vs. other forms of estrogen?
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The study I read was done with teriparatide (Forteo). People in the study were followed-up up to 2 years after teriparatide cessation. Unlike Prolia which could lead to rapid loss of bmd gained during treatment and sometimes dropping below pre-treatment levels (which could result in multiple VCFs) after cessation without a follow-up drug, there were no "rebound" phenomenon with teriparatide in the study. I'd imagine bone loss afterwards resume the rate at pre-treatment.
Raloxifene is not a hormone itself but it mimics estrogen's effects in some tissues such as bones while blocks estrogen's effects in breast and uterus tissues. It's a good choice for someone who is considering HRT but has breast/uterus cancer risks. I read that raloxifene does not help with menopause symptoms and its antiresorptive effects are weaker than a full dose estrogen.