Anyone had IsoPSA testing?

Posted by smoore4 @smoore4, Nov 21, 2024

“I would never want to belong to any club that would have someone like me for a member.”
- Woody Allen*, Annie Hall

Seriously, I know I am going to count on this group for plenty of things, so thought I would introduce myself - Steve, hi.

I am early in the PCa process. One of the diagnostic tests I had done was an IsoPSA (8.0). I don't see much chatter about that here, and I am wondering if it is because it is new, or it is not accepted as a standard test. Any thoughts?

* originally Groucho Marx

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

topf | @topf | Apr 7 12:41pm

In reply to @ialogic "My isoPSA is 47/psa 16. Biopsy mri negative" + (show)

😳 Mine was 13 and I thought it was through the roof.

jeff Marchi | @jeffmarc | Apr 7 4:22pm

In reply to @detroitmike "I have had iso psa 23 doctor was surprise how high it was ,had mri came..." + (show)

With that high an ISOPSA, you should be able to light up a PSMA PET scan because something is causing that number. Your result is high, IsoPSA >10 is associated with a sevenfold higher risk of csPCa (clinically significant prostate cancer).

You could do a PSMA Pet test before a biopsy just to see if there’s cancer somewhere else.

Would be interesting to see your actual PSA.

topf | @topf | Apr 7 7:07pm

In reply to @jeffmarc "With that high an ISOPSA, you should be able to light up a PSMA PET scan..." + (show)

My isoPSA was 13 and my PSMA did not light up like a christmas tree. There was some visible uptake but the report noted that it was not “abnormal”.

stldadof4 | @stldadof4 | Nov 1 8:15am

In reply to @ialogic "My isoPSA is 47/psa 16. Biopsy mri negative" + (show)

@ialogic really glad to hear this. My blood Iso PSA was 22.9, and everything I’ve read about that is concerning. Just had my MRI and will know the results next week.

stldadof4 | @stldadof4 | Nov 1 8:22am

In reply to @detroitmike "I have had iso psa 23 doctor was surprise how high it was ,had mri came..." + (show)

@detroitmike I have the same ISO result as you and just had my MRI, so I don’t know my pi rads yet. With a 2, did they still do a biopsy?

stldadof4 | @stldadof4 | Nov 1 8:26am

In reply to @topf "I had an IsoPSA done that came back at 13. Sure enough, I have G8 despute..." + (show)

@topf is G8 your Gleason score? I’m not familiar with that term.

jeff Marchi | @jeffmarc | Nov 1 10:44am

In reply to @stldadof4 "@ialogic really glad to hear this. My blood Iso PSA was 22.9, and everything I’ve read..." + (show)

@stldadof4
A common threshold used in studies is an IsoPSA index greater than 6, which is associated with an increased risk of cancer.

Your high ISO PSA sort of says you should get a biopsy soon. Good to hear you got an MRI, Sounds like your doctors on it.

topf | @topf | Nov 2 6:13am

In reply to @stldadof4 "@topf is G8 your Gleason score? I’m not familiar with that term." + (show)

@stldadof4 Yes, I was Gleason 8 upon Biopsy. Downgraded to 3+4=7 with the pathology after surgery.

Jonesfit65 | @jonesfit65 | Nov 2 5:51pm

In reply to @stldadof4 "@ialogic really glad to hear this. My blood Iso PSA was 22.9, and everything I’ve read..." + (show)

@stldadof4 Good luck & God's grace to you! This is the 1st I've ever even heard of IsoPSA, but then none of our Drs have offered much helpful info. Do we really have to wait till his PSA is greater than 4?! My husband's PSA went from 63 to 72 in 1 month early 2021 & they brought his PSA down to undetectable w/Lupron in less than 2mos. He has just begun an ADT Intermission w/every 3mo PSA! Wish us luck?!