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"if Kevzara or other biologics can treat PMR without the nasty side effects of Prednisone, why isn't that prescribed first?"
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The simple explanation is that biologics cost too much. Prednisone is as "cheap as chips" as some people say. However, I think the cost of treating the adverse effects from prednisone should be included in the cost analyses. For some people, there are nasty side effects from biologics too. That hasn't been my personal experience though.
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"My question is, is it better to tough it out with the pain as long as I can function, or would it be better to up my dosage, even marginally, and feel somewhat better?"
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In my opinion, this question needs to be individualized. I would ask myself if the "short term pain" of not increasing my dose was worth the "long term gain" of getting off prednisone. For me, the answer changed over time. Part of it was how "tolerable" the pain was. I couldn't tolerate the pain at the start. Over time, my personal evaluation of the pain changed.

I don't know if my "pain tolerance" increased or the pain was less. It was quite possible that both these things happened.

On the other hand -- there was an undeniable threshold of pain where I drew the line and increased my dose. There were other times when I took solace in the fact that the pain had been worse and I didn't increase my dose.

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Replies to ""if Kevzara or other biologics can treat PMR without the nasty side effects of Prednisone, why..."

Hi, I’m Amy. I agree 100% with this reply. Prednisone is a slippery slope, a love-hate relationship at best.

I started on prednisone at 15MG a day for my PMR. I went from agony to feeling great almost overnight. It was great, amazing a miracle drug. Then after a couple few months the side effects started. You all know what they are. Then the taper began, 2 pills, then 1 1/2 and now I'm down to 1 MG a day and a Kevzara shot every two weeks. With each reduction in dosage, the pain started to return. I'm not sure how much 1 MG a day helps but I will find out in a couple of weeks when I go off completely and I'm worried. Don't get me wrong, the pain is not as severe as it was but getting up from sitting, in and out of bed and the car, all the stuff has come back. I was wondering the same thing as all of you about once I go off but I'm going to try as the side effects, well I just don't want them and what they have done to my body. I hope the Kevzara is enough!!