Anyone use autologous serum eye drops (ASED)?

My eye doctor gave me a prescription. I had to go to a clinic who drew my blood. They created the serum from my blood - it looks like a yellowish substance. It was about 3 years ago and I can't remember what strength it was but it was about 15-20%. I tried them for about 6 months or a little more. They were for severe dry eye and although they feel good when inserted, I didn't feel that they gave me relief. I am in Toronto Canada area.

I received ASEDs for a "nerve related" condition but not nerve pain. My condition is called neurotrophic keratitis.
https://www.ncbi.nlm.nih.gov/books/NBK431106/#:~:text=Neurotrophic%20keratitis%20is%20a%20degenerative,corneal%20ulceration%2C%20melting%20and%20perforation.
I developed a neurotrophic corneal defect but I didn't feel any eye pain because my left eye is completely numb. The lack of innervation to my left eye was caused by surgery for trigeminal neuralgia.

My ophthalmologist didn't think I was diligent with doing all the eye drops she wanted me to take. She reminded me how serious the situation was and what could happen. She said my eye could get an infection, my cornea could "melt down" which could cause a perforation of my eye. None of this sounded good so I did the ASEDs at least 8 times per day.

I had to do other eye drops besides ASEDs. I was doing eye drops hourly at one stage. My ophthalmologist seemed to know that ASEDs 8 times per day wasn't feasible when she settled for "as often as possible."

When it was all said and done ... my corneal defect healed eventually.

I was diagnosed with NK last year. Was on oxervate for 8 weeks 6 times daily. Finished in February. My eye felt a little better. Tried a scleral lens after for 11 days but felt uncomfortable. Stopped taking now my eye is more irritated. Have a F/U with my ophthalmologist. Thinking about trying this blood serum. How long did it take to heal?

I don’t use them for your condition, but for extreme dry eyes caused by an autoimmune syndrome. For this condition, they have worked better than any of the very expensive prescription eye drops.

I don’t use them for your condition, but for extreme dry eyes caused by an autoimmune syndrome. For this condition, they have worked better than any of the very expensive prescription eye drops.

I never considered how cost effective ASEDs were. One blood draw gave me an entire year supply of ASEDs. There was a processing cost that was billed to insurance so I didn't pay much out of pocket. I was more focused on how gross the ASEDs seemed.

You are right , the Refresh celluvisc eye drops I now use for NK are expensive.

@edie2716 ... my corneal defect healed slowly but it finally closed after about 6 months. The ASEDs helped. I was diligent about the ASEDs because I didn't want to waste them. My ophthalmologist made sure that I understood how serious it was. I didn't like thinking about the corneal meltdown scenario.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3420049/

I never considered how cost effective ASEDs were. One blood draw gave me an entire year supply of ASEDs. There was a processing cost that was billed to insurance so I didn't pay much out of pocket. I was more focused on how gross the ASEDs seemed.

You are right , the Refresh celluvisc eye drops I now use for NK are expensive.

@edie2716 ... my corneal defect healed slowly but it finally closed after about 6 months. The ASEDs helped. I was diligent about the ASEDs because I didn't want to waste them. My ophthalmologist made sure that I understood how serious it was. I didn't like thinking about the corneal meltdown scenario.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3420049/

I was wondering what your NK symptoms were? How did your eye feel and when it healed 6 months later did the symptoms go away?

I didn't feel anything. I don't have any sensation in my left eye. The entire left side of my face including my left eye is completely numb except for an uncomfortable tingling sensation.

It isn't very common but I had complications after surgery for trigeminal neuralgia. I wasn't supposed to have any facial numbness after my microvascular decompression (MVD) surgery. No mistakes were made. The neurosurgeon said he did the best he could under the circumstances. He said the odds of finding the problem I had were astronomical. The pre-op MRI didn't reveal the nature of the problem. I was just grateful the pain of trigeminal neuralgia stopped and I can live with the facial numbness.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5849951/
----------------------
About 5 years after my MVD surgery I went for a "routine eye exam" and my ophthalmologist informed me I had a corneal defect that must have opened up spontaneously. I didn't remember any injury to my left eye. She said the defect should have been extremely painful and was incredulous that I didn't feel anything.

It was incredible how my regular ophthalmologist reacted but I didn't feel anything. A couple other ophthalmologists looked at my eye but eventually a cornea specialist was called. The cornea specialist recommended the ASEDs because none of the other ophthalmologists were sure what to do.

I didn't feel any different 6 months later after the corneal defect closed. I was happy the defect closed though. The talk about a "corneal meltdown" was very scary.
https://iovs.arvojournals.org/article.aspx?articleid=2767790