I’ve been on HU for PV since 2021.. My platelets have dropped and been flagged as low (120 or below) for the past 2 years.. I’ve been as low as 91 which seems concerning but this is not an issue according to my hematologist/oncologist and I actually have felt great thru this to date… I exercise daily; ride the bike weather permitting and swim at a recreational center every day.. HU seems to impact people differently when it comes to side effects and test results..