You won't really know anything until at least three months after you stop taking Orgovyx. While on Orgovyx my PSA was 0.01. My first PSA test, two months after Orgovyx was .08. My second one this month was .04. According to Harvard medical, for radiation treatment: "Recent studies have shown that for optimal results, PSA levels should be lower than 1 ng/ml, and even lower than 0.5 ng/ml. Levels that are above 1 or 2 ng/ml 12 to 18 months following completion of radiation treatments are very worrisome, because they indicate that the cancer may not have been eradicated." The gist of the article is that 0.5 or lower after a year is very good sign, but < 1 ng/ml is still OK.

My oncologist told me that as long as I stay below 2 ng/ml I'm good and that PSA will bounce around a bit, i.e. don't freak out if one reading is suddenly higher as long as it's below 2 ng/ml. Other oncologists use something called a "nadir" (the lowest PSA you reach) as the starting point and if you go more than 2 ng/ml above that it's a sign the cancer has returned.