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Bone marrow biopsy and/or blood tests for MGUS
Blood Cancers & Disorders | Last Active: 5 days ago | Replies (28)Comment receiving replies
My hemanoc was amazing. I was diagnosed with IGG Kappa MGUS at 36. I am 43 now and I started getting bloodwork every 6 mths but now we are doing 4 mths due to the numbers rising. They don’t rush to do a BMB until they run all the bloodwork. Your first appt should be a baseline. Full bloodwork plus Immunoglobulin panel, IFE and PE, Serum, kappa lambda ratio, Beta-2 Microglobulin Etc. and a 24hr IFE+Protein Electro. Skeletal survey. Then after those results they can diagnose. MGUS does not have symptoms so if you have some make sure you rule out autoimmune diseases which can skew numbers. Most everyone who is diagnosed with MGUS are older then 65 but and only 1% will move to myeloma or other blood cancers. Hope this helps
Replies to "My hemanoc was amazing. I was diagnosed with IGG Kappa MGUS at 36. I am 43..."
I found this information which I believe is credible. The article source is attached.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1895159/
“MGUS is associated with progression to multiple myeloma or related malignancy at a rate of 1% per year. Thus the risk of malignancy for a 50-year-old patient with a 25-year life span is 25%. However, the risk of progression does not diminish even after 25 to 35 years, making lifelong follow-up by primary-care providers necessary in all persons diagnosed with MGUS.”
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Wow, good information on what tests to get. I was just diagnosed a few weeks ago so when I get labs next in 3 months I’ll ask about some of the tests (skeletal survey, 24 hr one) he didn’t do.
Additionally, from my readings, it’s 1% per year. I interpret that meaning 20% if one lives 20 years. But at any rate, the risk is low. Many people have it before 65 but it is only found coincidentally in most cases. We caught it because of my symptoms of energy crashes and leg pain, and bunches of serial abnormal labs like anemia, low wbcs, rbcs as well as extra large red blood cells. I suspect my next set of numbers may change my diagnosis but I try to stay away from “borrowing trouble.”