Oh gosh. I was sick for a week after my 1st infusion. Severe!! pain in every arthritic joint; couldn’t use my hands, left leg hurt to walk so I shuffled, 102 fever for days. I have another one at the end of April and I schedule off work for the week. I can’t take ibuprofen because of kidney issues and Tylenol did nothing. I would decline the treatment except there’s research that shows zoledronic acid can protect against metastatic bone cancer.