Hi. I have used the Inbrija Inhaler a number of times when my Rytary is just not taking care of my symptoms of PD. At first I did not seem to get any relief or improvement in my symptoms. (The main symptom that I am having trouble with is freezing. ) The last few times that I have used the Inbrija I have noticed that sometimes it helps with my freezing and sometimes it doesn't. It can be a little difficult to use- it causes me to cough so I don't get the full effect of the medication. But as I am able to use it better and it does seem to be helping more. If it is going to work it kicks in within minutes and seems to last around 30 to 45 minutes. I do not know why it help sometimes and not other, but it is very frustrating. It would be nice if you could predict if it would help and how much if would help. But than what is predictable about Parkinson's. Another thing that I try if the Rytary is not working well is crushing a Sinemet (I was on Sinemet before the Rytary) and diluting it with a small amount of carbonated beverage, such as coke. It has to be a carbonated beverage. This also sometimes works and sometimes doesn't. This was suggested to me by the YOPD neurology specialist that I see at Mayo Rochester. I did talk to the specialty pharmacy that I get the Inbrija from and they said that if I am going to try using both, to wait at least an hour between using the Inhaler and using the crushed Sinemet. Hope this information is useful to some of you. If you have any questions or comments, please feel free to share with me.