D-Mannose in POWDERED form has been Life changing! I went from having UTI's almost every month and becoming anti biotic resistant to being UTI free for the last 14 months while on D-Mannose in POWDERED Form. Capsule form is not effective. Cranberry juice is useless. For an acute UTI: I take 1 teaspoon rounded (2000+ mg) every 2-3 hours with 1/2 cup of water, for 5 days. Yes, you need to wake up throughout the night to take your dose. Taking higher doses may cause diarrhea. Wait for 45 minutes to an hour. Then, drink plenty of water in order to flush out the bladder and get rid of E-Col. Then reduce the frequency to a Preventive Dose of ½-1 teaspoon (I take 1 rounded tsp) one to two times a day for long term maintenance. Take D-Mannose as early as possible when you first notice symptoms, before the UTI fully develops. Why in the world is D-Mannose in powdered form not recognized by the medical community as the cure that it is!!! Remember, ONLY take D-Mannose in POWDERED form! I buy PURE D-MANNOSE or NOW brands in bulk from Amazon.