Thanks for the link to this study. I've been on a statin for more than 25 years and ezetemibe added about 15 years ago. The combination lowered my total cholesterol from 423 to about 178 and LDL from 250 to around 100. Great decrease but family genes said not good enough, so last year Repatha was added to the mix. Total cholesterol down to 87 and LDL at 17 now.