I have suffered for decades with RLS and found mine was made far worse by the bupropion (wellbutrin) i was taking for depression. I was on 300mgXL and doing fine on just 75 mg now. I was able to reduce my Sinemet which helped a lot from 6 tabs a day to 1/2 tab 3x a day. Be sure to check your meds to see if any cause RLS as a side effect. RLS is often multifactoral in cause but reducing any cause is worth it to get some relief from this miserable problem!