I have been taking prednisone since I was 16. Different doses but I have been on 5mg for years. At 5mg I gave no side effects. My liver disease was autoimmune chronic liver disease. I also tale .5mg of tacrolimus 2xa day. Also cellcept 500mg 2 x a day. I am 38 years out from my transplant and still pretty darn good. I am very thankful.