Hello @ponygirlnd. I had radiation to my ear area directed to focus where the facial nerve exits from the skull. I had this done at the University of Michigan where I had been referred to a world renowned radiation oncologist, This old German guy, Dr. Eisbruch, definitely said that I would have some short term memory loss and possibly other brain issues from the radiation penetrating through the brain to get to the site intended. He said it may not happen quickly, but could worsen with time. As a 71 year old and 13 years since radiation, who knows if memory loss is age or radiation at this point, so it is hard to know how much it has affected me. I also knew a woman who had whole brain radiation for her brain metastases. She had a distinct personality change from that and fairly quickly afterward. My ENT doctor at Mayo Clinic also says that my worsening hearing loss on the right side is most likely a result of radiation even this long afterward. So my experience is yes, there are long term effects to brain tissue from brain radiation. The brain plasticity, though, allows for regrowth of new nerve pathways to improve symptoms over time. Nervous system tissue is quite slow to heal so this can be a long process. I was told from the start right after my skull surgery that I would need to "retrain my brain" to lose the dizziness and loss of balance that it caused. So continuing to challenge yourself with the things you are struggling with can actually create improvement, no matter how slowly. It has worked for me, not 100%, but definite improvement. What challenges are you having from your radiation?