There is much to consider before a SCT. Besides the medical aspects, there are also the logistics such as lodging and relocating, usually for several months.
In response to your comment about medications for a lifetime…Initially there are several medications necessary such as anti-rejection meds, along with medications which will act as a temporary immune system. For many of us though, once we reach a certain point in our recovery, we’re no longer on any medications. That varies by individuals.

With your husband’s MDS classified as high risk and already receiving many blood and platelet transfusions while in treatment, it’s my understanding that it would be unlikely for him to reach a durable remission without the transplant.

He would most likely continue as he is now with his current treatment plan or similar, along with transfusions.
I think it would be very helpful to meet with a transplant doctor to get all the information and ask questions. It would give you a clearer picture of what to expect and maybe have you both feeling a little more comfortable with the decision…either way.
I’m here anytime as a sounding board, along with my fellow BMT friends who have jumped into this conversation too. We want to help with whatever you decide.
What is your husband’s biggest concern with having the SCT?