As it lowers our platelet count, HU can change our blood in other ways too.

After about a year and a half on HU, I got test results that were "off." Worried, I asked my oncologist, and was assured that this is a side effect of HU, not a new problem.

The essential priority is lowering your platelet count.

It sounds like you're doing everything right: tracking your results and asking questions when something changes. Hang in there!

P.S. Just this week I was told to up my HU, as my platelet count's still too high. So unfortunately I understand what you're going through.