Unfortunately I have not heard many, if any positive outcomes with the use of Ohtuvayre! So much hype but not power packed. Ohtuvayre was developed to help those with COPD with a CB phenotype (chronic bronchitis) so not appropriate for COPD without bronchitis. I started Dupixent in November 2023 and had great results with it for about 5 months, significantly decreased secretions. Have tried literally everything with little success in secretion management. Finally, my treatment team thought perhaps I should see an Allergist/pulmonologist. Hopefully, we will find a reason that the Dupixent effect waned - antibody formation, maybe. Just started Daliresp at 500 mcg today so am giving that a try. Keeping my fingers crossed!