Ampullary cancer: What are the chances of surviving?

Simple Summary
Ampullary adenocarcinoma is a rare tumor in the gastrointestinal tract. Surgery is the preferred treatment, however if a patient has other medical conditions or advanced disease, surgery may not be possible. In this situation, the best treatment strategy is unknown. We sought to find out what happens to these patients in terms of treatments and survival. We used the National Cancer Database 2004–2017 to find 2176 patients who were diagnosed with ampullary adenocarcinoma but did not undergo surgery. The majority of these patients did not receive any chemotherapy or radiation. The rest received a combination of chemotherapy, palliative radiation, and/or definitive radiation. One-year overall survival ranged from 35% in patients who only received palliative radiation to 59.4% in patients who received chemotherapy and definitive radiation therapy. We did not find a significant difference in survival between patients who received chemotherapy and those who received chemotherapy and definitive radiation therapy.
Abstract
Surgical resection is the standard of care for ampullary adenocarcinoma (AC). Many patients are ineligible due to comorbidities/advanced disease. Evidence for the optimal non-operative management of localized AC is lacking. We hypothesize that patients treated with chemotherapy (CT) and definitive radiation (DRT) will have superior survival (OS) compared to those treated with CT alone. We performed a retrospective review of the National Cancer Database from 2004 to 2017 to identify patients with non-metastatic AC and no surgical intervention. Patients were categorized as having received no treatment, palliative radiotherapy (PRT) alone, CT alone, CT + PRT, DRT alone, or CT + DRT. We utilized Kaplan–Meier analysis to determine OS and the log-rank test to compare survival curves. Among 2176 patients, treatment groups were: No treatment (71.2%), PRT alone (1.9%), CT alone (13.1%), CT + PRT (1.6%), DRT alone (2.4%), and CT + DRT (9.7%). One-year OS varied by treatment group, ranging from 35.1% (PRT alone) to 59.4% (CT + DRT). The one-year OS in a matched cohort was not significantly different between CT alone and CT + DRT (HR 0.87, 95% CI 0.69–1.10, p = 0.87). Most patients with non-metastatic AC not treated with surgery do not receive any treatment. There is no difference in one-year OS between those undergoing CT alone and CT + DRT.

Thanks to the dedicated skillful medical team and early discovery of the ampullary cancer, I had successful Whipple Procedure 5 years ago. I will soon be 87, relatively in good condition, with no major health issues to speak of. Due to my advanced age I did not get chemotherapy, judging from the results probably did not need it. Few days after the Whipple, I was up on my feet, diligently walking a few times a day in the hospital corridors. I was surprised how well I did, because 18 years ago I had a quadruple coronary bypass operation and following that for couple of weeks if I may say, I was sick as a dog. My last blood test and CT scan in January and 6 months intervals before that were excellent, no trace of recurrence. If I may add I am physically active, try to eat wholesome food, less meat, more vegetables, and strictly one meal daily which is only a generous serving of 3-4 kinds of in season fruits only.

Hi @richjh, I see that you posted an excerpt from this journal article:
- Treatment Patterns and Outcomes for Patients with Ampullary Carcinoma Who Do Not Undergo Surgery https://pmc.ncbi.nlm.nih.gov/articles/PMC10378072/

Have you been diagnosed with ampullary adenocarcinoma? What treatment(s) did you have?