MGUS the twists and turns and hopeful.
My MGUS journey (diagnosed Nov, 2024)has taken some interesting turns. The whole body scan, revealed masses on the adrenal glands and sigmoid colon. CT scan of adrenal glands determined benign mass BUT identified aneurysms with arterial dissections in the celiac artery, hepatic artery and splenic artery. Very rare. They thought it was due to a past trauma but I can’t remember anything specific. Repair at this time has more risk than potential benefit. So it’s another, watch it every 6 months for increased enlargement. My colonoscopy is scheduled this coming Thursday.
Last week my EMG confirmed peripheral neuropathy. MGUS related or B12 deficiency? A lab test this past January revealed the low B12 level and I have started B12 shots. Fingers crossed it helps the neuropathy. I know about the correlation of MGUS and neuropathy. Just wondering how many MGUS/neuropathy individuals also have low B12? Diabetes is also related to neuropathy. Does that also correlate to MGUS/neuropathy?
Now the HOPFUL and may have been presented before in this forum but I think it is something to keep an eye on. A study is looking at the potential of Metformin (diabetes agent) slowing the progression of high risk MGUS and SMM towards multiple myeloma. The study is completed and should be released this summer?
A new population study (this is an observational study in contrast to the Metformin study which is a randomized trial) just caught my attention regarding the GLP-1 diabetes agents slowing the progression of MGUS in diabetics.
“Association between glucagon-like peptide-1 receptor agonist use and progression of MGUS to multiple myeloma among patients with diabetes “
In short a 55% reduction in progression.
Would this same benefit be seen in prediabetics. I am one of those. Or even in MGUS individuals without diabetes?