pemetrexed and carboplatin pembrolizumab side effects

Posted by chedder2008 @chedder2008, 5 days ago

Hello, My husband is due to start his first treatment of pemetrexed and carboplatin pembrolizumab. I was wondering the side effects and anything that I can do to help lesson.

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If he can, rest on the days after treatment. About day three or four it hits one really hard. Keep up on the anti nausea meds. It’s been two years for me since going through same. Bless you both as you go through this journey.

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@dianemb

If he can, rest on the days after treatment. About day three or four it hits one really hard. Keep up on the anti nausea meds. It’s been two years for me since going through same. Bless you both as you go through this journey.

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Thank you so much for your commment and response. This is all new to me and as the main person who has always cared for us, it is quite daunting and down right scary for me. It is so refreshing to hear that you are going on 2 years and able to give me the advice and help I need. Any ideas for food menu? Liquids?

Many many more blessing for you!!

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I did this combo starting over a year ago and am still taking the pemetrexed every three weeks. My stomach bothers me occasionally but not bad, not enough to affect my eating. It does make me a little tired and can take a while to get going on something, but usually when I get moving and start moving enough that kind of goes away. It doesn't seem to be as bad as some of the other chemo regiments out there. I do have high liver enzymes which could be the pemetrexed or Tagrisso my doctor tells me, but I think this is not a common side effect.

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@codym

I did this combo starting over a year ago and am still taking the pemetrexed every three weeks. My stomach bothers me occasionally but not bad, not enough to affect my eating. It does make me a little tired and can take a while to get going on something, but usually when I get moving and start moving enough that kind of goes away. It doesn't seem to be as bad as some of the other chemo regiments out there. I do have high liver enzymes which could be the pemetrexed or Tagrisso my doctor tells me, but I think this is not a common side effect.

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That is so helpful and hopeful for us. Thank you for all of your help.

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@chedder2008

Thank you so much for your commment and response. This is all new to me and as the main person who has always cared for us, it is quite daunting and down right scary for me. It is so refreshing to hear that you are going on 2 years and able to give me the advice and help I need. Any ideas for food menu? Liquids?

Many many more blessing for you!!

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I remember only having an appetite for mild foods, mashed potatoes and rice. I went through standard treatments for my nsc lung cancer. Eventually I was admitted to a targeted therapy study in August 2023. I take it every day and I feel very well, numbers are good. As our mentor here wrote we all have unique experiences but I hope this gives you encouragement. I can’t say enough good things about my oncology team at Mayo.

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@dianemb

I remember only having an appetite for mild foods, mashed potatoes and rice. I went through standard treatments for my nsc lung cancer. Eventually I was admitted to a targeted therapy study in August 2023. I take it every day and I feel very well, numbers are good. As our mentor here wrote we all have unique experiences but I hope this gives you encouragement. I can’t say enough good things about my oncology team at Mayo.

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I am so happy you are doing well and able to share your journey with me. 🙂 You do not know the joy and happiness and hope you have given me. We are currently seeking Mayo as a second opinion. UW has a treatment plan but the Oncologist we have just didnt sit well. We are hoping to hear good news from the Mayo Clinic and pay out of pocket if needed.

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I am currently in this treatment. I recommend starting stool softeners when receiving the chemo. My doctor had me get something to prevent diarrhea but that hasn't occurred, I do get constipated. At a recent patient education conference sponsored by LiveLung, a nurse practitioner suggested that we use a softener and, if need be, a laxative to push it through.

The chemo leaves me with an odd taste in my mouth. Lemon drops seem to balance that out.

Also, 5-6 small meals instead of 3 regular meals. Have healthy snack options on hand.

Edit to add: add a protein shake, bar, or powder to the mix. It helps rebuild blood levels. I had to postpone my second chemo because my white blood count was low.

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Hi,
My husband is also about to start the same chemo regimen next week. I am a cancer survivor myself (different type) and survived 4 rounds of a different type of chemo, so I have some idea about the issues. But everyone is different, of course. I really appreciate your posting this and all the helpful comments you have received. His liver enzymes are moderately elevated but he was on some heavy duty antibiotics so the oncologist says that is probably why. We are keeping our fingers crossed for good blood work before treatment on Tuesday. Good luck to you!

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@denzie

I am currently in this treatment. I recommend starting stool softeners when receiving the chemo. My doctor had me get something to prevent diarrhea but that hasn't occurred, I do get constipated. At a recent patient education conference sponsored by LiveLung, a nurse practitioner suggested that we use a softener and, if need be, a laxative to push it through.

The chemo leaves me with an odd taste in my mouth. Lemon drops seem to balance that out.

Also, 5-6 small meals instead of 3 regular meals. Have healthy snack options on hand.

Edit to add: add a protein shake, bar, or powder to the mix. It helps rebuild blood levels. I had to postpone my second chemo because my white blood count was low.

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very helpful. thank you. do you take the stool softener every day, regardless, or wait till you need it?

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I'm still figuring it out. This next cycle I'm going to do it through chemo as I have been waiting until the stool is hard lumps. Like type #1 or 2 on the Bristol Stool Scale. That's been too late. I'll try to remember to let you know how this round goes. Chemo number 4 starts on Wednesday.

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