Hi @dax1million. Try not to be too discouraged after yesterday’s appointment. I know, that’s easier said than done. Just hearing the words that your husband has leukemic cells was unsettling. But realistically your husband was only very recently diagnosed with MF and hadn’t been on any treatment. So it wouldn’t be unusual to have leukemia cells present.
He’s now starting a round of Vidaza which is a very effective drug for killing cancer cells. Sometimes that medication is paired with another. But this first application will allow the doctor to evaluate the effectiveness of reducing the cancer cells and see how your husband tolerates the medication.
He may still have platelet infusions for a while yet and possibly a red blood transfusion. Chemotherapy can reduce the over all amounts of blood cells, along with the cancer cells, within a few weeks after the last treatment. Then the healthy cells regenerate and the numbers start climbing again. That’s a fairly standard reaction to a cycle of chemotherapy.

So hang in there! Both of you! This is all new and uncertain but you’ll get through one day at a time. I think you could use a little encouragement. So I’d like to introduce you to a couple of members who have been taking Vidaza and Venetoclax for a few years and remain in remission from AML. Please meet @lindagi and @dancouclanel4
Both have shared their positive and encouraging experiences, along with others in this discussion:

AML successful treatment
https://connect.mayoclinic.org/discussion/aml-successful-treatment/
This medication has been really successful for so many people who are not candidates for a bone marrow transplant.

We’ve been chatting in the support group with members talking about Hydroxyurea experiences. Since your husband isn’t taking HU, let’s get you over to a more suitable discussion. Here are a couple of options of current conversations.

What are treatments for Myelofibrosis?https://connect.mayoclinic.org/discussion/mylofibrosis-1/
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Myelofibrosis:
https://connect.mayoclinic.org/discussion/myelofibrosis-24a025/
Feel free to post in either of those two discussions where you’ll meet other members with MF.
When is your husband’s first treatment?

You'll never meet us, Dax1million, but all of us are keeping you and your husband in our hearts and prayers.