If you don't mind me asking, what are your IgA/M/G numbers? I am considered a MGUS patient on the wait and watch program. My IgA is in the lower part of the normal range, my IgG has been a little on the low/normal side, and IgM and M-protein levels were rising at an alarming rate. Everything else normal.
The last three months, I've taken 6 g/day of curcumin with the belief that there was little downside and some potential benefits. It seems the IgM progression has slowed but my IgG dropped and I also recently read a very small MGUS study where the only person with IgM MGUS seemed to not do as well on curcumin. The others in the study seemed to benefit.
So yesterday I stopped taking the curcumin and now my plan is to ask about getting....
Bone marrow biopsy → Confirm B-cell involvement.
Serum viscosity test → Assess hyperviscosity risk.
Flow cytometry → Check for clonal B-cell population.
Discuss IVIG therapy → To address low IgG & infection risk.

IgM Levels (Normal: 40–230 mg/dL)
Mar 3, 2025: 1,611 mg/d
Nov 4, 2024: 1,608 mg/dL
May 13, 2024: 1,005 mg/dL
Oct 2, 2023: 774 mg/dL
Apr 19, 2023: 548 mg/dL

IgG Levels (Normal: 700–1,600 mg/dL)
Mar 3, 2025: 596 mg/dL (Low)
Nov 4, 2024: 640 mg/dL (Low)
May 13, 2024: 618 mg/dL (Low)
Oct 2, 2023: 693 mg/dL (Low)
Apr 19, 2023: 677 mg/dL (Low)

M-Protein (Normal 0.0 g/dL)
Mar 3, 2025 1.17g/dL
Nov 4, 2024 1.22g/dL
May 13, 2024 0.64g/dL
Oct 2, 2023 0.54g/dL
Apr 19, 2023 0.46g/dL