I have had CMML/Myeloproliferative disease for ten years and have tried everything for itching. I currently take 10 mg Jakafi but still have some itching. Tried a higher dose but it caused skin cancers. Antihistamines don’t really help, although they make you sleepy which might get you through the night. Here’s what has worked for me. First, eliminate anything that might cause itching by using a good soap (I use Bioderma Atoderm) and detergents like All free and clear. Immediately after showering I use jojoba oil all over my skin. It’s not really an oil—more like a wax so it absorbs well. It washes out of clothing and I really use a lot. And I sleep with an ice pack. I get refillable ice bags with a clamp closure on Amazon. The ice seems to stop the itching faster than cortisone and is a lot less expensive. After many years of trying things this is what is working for me. Good luck to all of you.