Welcome, my wife had Avistin and had side effects. Everyone is different, but her side effects were high blood pressure, pain in feet and hands, frozen shoulders, and tiredness. That makes it hard for sleeping due to shoulder and other pains. She continues on Avistin until September one infusion every three weeks. We went to the Orthology clinic and will do another Scan to see if she can receive cortisone shots in her shoulders. Physical therapy sessions will follow and we have been to two sessions already. We do some physical therapy at home based upon what the PT said. She stays as active as she can stand in order to get over the pain and stiffness. It will also speed up recovery after the Avistin is over. Hope this helps.