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← Return to Risedronate Sodium 150mg
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@mayblin, Good to hear from you. I have not got my use of Risedronate as an interim med in between two rounds of Evenity worked out. Hopefully I am not losing bone but clearly once monthly Risedronate is not holding my CTX down to where I'm guessing it should be.
Here is what's been happening:
Date Osteo Med Testing
09-30-24 Last Evenity shot
10-31-24 264 pg/ml CTX
11-16-24 Risedronate 1
12-13-24 371 pg/ml
12-16-24 Risedronate 2
12-30-24 Risedronate 3
01-14-25 169 pg/ml
01-19-25 Risedronate 4
02-17-25 396 pg/mL
02-21-25 Risedronate 5
My current plan is to just start taking the monthly Risedronate dose every 2 weeks. You can see that I did that with Risedronate dose 3 and it brought my CTX down into a desirable range right away. Otherwise it has not been able to keep the CTX score down.
I've checked the early Risedronate studies and there was no evidence of any side effect issues with increasing the dosage up to 200mg a month. I will be taking 300mg a month in 2 divided doses. There was no attempt to study a higher amount for osteoporosis. A higher amount was taken short term in studies to help Paiget's disease and there were no significant issues with 30mg a day for up to 3 months and for a few patients nearly 6 months. I'm judging from these studies that two 150mg doses is not risky and should get my CTX down to a better level. I'm not having any side effects worth mentioning.
Any thoughts or comments that you might have would be appreciated. Hope you are doing well.
Replies to "@mayblin, Good to hear from you. I have not got my use of Risedronate as an..."
@awfultruth , I appreciate it very much for your first hand information! It's interesting how your CTX presented and responded to dosing variation. Guess there are a few challenges: there might be a latency period for the full effectiveness of oral tablets to achieve your desired CTX. Also, terminal half life for once monthly dosing of risedronate (~23days) may affect your CTX readings, or at least at the beginning. As I recall, your baseline CTx prior to evenity was kinda high - if it returns to that level, you may need extra effort to suppress it.
The drug information which the manufacturer provided indicates that for men treated with 35mg actonel/wk, CTX has a mean decrease of 45% compared to placebo; for postmenopausal women with osteoporosis treated with actonel 150mg/month, urine NTx was decreased by 49%. And bone turnover markers reached a nadir below baseline within about 6 months of treatment.
The larger decrease in CTX I was talking about in my last post was from this paper:
https://pubmed.ncbi.nlm.nih.gov/17500121/
The pdf version can be downloaded via another site. In this study, they used 10mg/day risedronate x1yr and achieved suppression of CTX from 800 to -~mid 100s at end of one month and remained low thereafter. Total monthly dose is the same as that in your 2x monthly dosing, but with a different dosage and dosing regimen.
Based on above information, dosage, dosing regimen and baseline CTX level may make a difference in achieving desired CTX.
It will be a trial and error for anyone who tries to use a sensible "relay" drug without a lot of established protocol. My use of a low dose HRT after Forteo turned out to be a surprise too - CTX reached a low of 163 at 6mo. Now I have to watch it closely too to avoid the oversupprssion of bone remodeling.
Hope your CTX stabalizes soon, and, please keep us posted!
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Thank you so much for this information! I too was on Evenity, 10 months and then my dexa read stage FRANK. Was very upset because out of pocket I paid a lot of money per injection. Understand not all drugs work the same for everyone.
Glad you're doing better with Risedronate!