I missed one dose (currently on 75 mg) because I couldn't remember if I had taken it or not, and wanted to err on the lesser rather than greater amount. I was so dizzy it was difficult to drive! This is what I despise about this medication! To be held hostage by a capsule is scary...think about if I was suddenly without my prescription, I would be completely helpless, and it's not like it has ever really done me any good anyway! Makes me so angry at these drug companies and doctors.