I tried different statins for 20 yrs - always had to get off due to overwhelming muscle and fatigue issues. Just last year sought advice from a lipid specialist who stated my diet and health choices were not the problem and identified a familial/genetic link to my mixed hyperlipidemia, and also advised against statin use for me. I was prescribed Nexlizet - a combo of bempedoic acid and Zetia. Not a statin. Working so well I was able to cut dose from daily to every other day, and there have been none of the problems I experienced with statins.